Cardiovascular disease is the leading cause of mortality among women in the United States. Epidemiologic studies have shown that women with adverse pregnancy outcomes, such as preeclampsia, are at increased risk for hypertension, cardiovascular diseases, and kidney disease later in life. To better understand how pregnancy outcomes are linked to future heart health, the nuMoM2b Heart Health Study researchers have followed the original nuMoM2b cohort for several years after pregnancy (2014-2020), including a clinic visit to collect research information at about 2 to 7 years postpartum for eligible women. The initial results of the Heart Health Study confirm that women with adverse pregnancy outcomes have, on average, more early indicators of cardiovascular disease risk than their counterparts without adverse pregnancy outcomes. To learn more about the nature of this association, Heart Health Study researchers will continue to follow the cohort during 2020-2027 using online and phone contacts, a clinic visit in 2022-2024, and additional in-depth ancillary studies. It is hoped that information from this follow-up study may be used to improve the health of women based on their experiences during pregnancy.

nuMoM2b participants helping to relate pregnancy experiences to future heart health

Key Study Goals

  1. Define the cardiovascular disease risk profile of women who experienced adverse pregnancy outcomes.
  2. Identify characteristics in early pregnancy that indicate increased risk for cardiovascular disease.
  3. Determine if sleep-related breathing disorders during pregnancy and postpartum are associated with increased cardiovascular disease risk.
  4. Identify factors during and after pregnancy that can be modified to improve cardiovascular health.